NOTCH | sp|P82279|CRUM1_HUMAN

Section I. Input Sequence and Domain Partition (help)

1
M
3
A
3
L
3
K
3
N
3
I
3
N
3
Y
3
L
3
L
3
11
I
3
F
3
Y
3
L
3
S
3
F
3
S
3
L
3
L
3
I
3
21
Y
3
I
3
K
3
N
3
S
3
F
3
C
3
N
3
K
3
N
3
31
N
3
T
3
R
3
C
3
L
3
S
3
N
3
S
3
C
3
Q
3
41
N
3
N
3
S
3
T
3
C
3
K
3
D
3
F
3
S
3
K
3
51
D
3
N
3
D
3
C
3
S
3
C
3
S
3
D
3
T
3
A
3
61
N
3
N
3
L
3
D
3
K
3
D
3
C
3
D
2
N
2
M
2
71
K
2
D
2
P
2
C
2
F
2
S
2
N
2
P
2
C
2
Q
2
81
G
2
S
2
A
2
T
2
C
2
V
2
N
2
T
2
P
2
G
2
91
E
2
R
2
S
2
F
2
L
2
C
2
K
2
C
2
P
2
P
2
101
G
2
Y
2
S
2
G
2
T
2
I
2
C
2
E
2
T
2
T
2
111
I
2
G
2
S
2
C
2
G
2
K
2
N
2
S
2
C
2
Q
2
121
H
2
G
2
G
2
I
2
C
2
H
2
Q
2
D
2
P
2
I
2
131
Y
2
P
2
V
2
C
2
I
2
C
2
P
2
A
2
G
2
Y
2
141
A
2
G
2
R
2
F
2
C
2
E
2
I
2
D
2
H
2
D
2
151
E
2
C
2
A
2
S
2
S
2
P
2
C
2
Q
2
N
2
G
2
161
A
2
V
2
C
2
Q
2
D
2
G
2
I
2
D
2
G
2
Y
2
171
S
2
C
2
F
2
C
2
V
2
P
2
G
2
Y
2
Q
2
G
2
181
R
2
H
2
C
2
D
2
L
2
E
2
V
2
D
2
E
2
C
2
191
A
2
S
2
D
2
P
2
C
2
K
2
N
2
E
2
A
2
T
2
201
C
2
L
2
N
2
E
2
I
2
G
2
R
2
Y
2
T
2
C
2
211
I
2
C
2
P
2
H
2
N
2
Y
2
S
2
G
2
V
2
N
2
221
C
2
E
2
L
2
E
2
I
2
D
2
E
2
C
2
W
2
S
2
231
Q
2
P
2
C
2
L
2
N
2
G
2
A
2
T
2
C
2
Q
2
241
D
2
A
2
L
2
G
2
A
2
Y
2
F
2
C
2
D
2
C
2
251
A
2
P
2
G
2
F
2
L
2
G
2
D
2
H
2
C
2
E
2
261
L
2
N
2
T
2
D
2
E
2
C
2
A
2
S
2
Q
4
P
4
271
C
4
L
4
H
4
G
4
G
4
L
4
C
4
V
4
D
4
G
4
281
E
4
N
4
R
4
Y
4
S
4
C
4
N
4
C
4
T
4
G
4
291
S
4
G
4
F
4
T
4
G
4
T
4
H
4
C
4
E
4
T
4
301
L
4
M
4
P
4
L
4
C
4
W
4
S
4
K
4
P
4
C
4
311
H
4
N
4
N
4
A
4
T
4
C
4
E
4
D
4
S
4
V
4
321
D
4
N
4
Y
4
T
4
C
4
H
4
C
4
W
4
P
4
G
4
331
Y
4
T
4
G
4
A
4
Q
4
C
4
E
4
I
4
D
4
L
4
341
N
4
E
4
C
4
N
4
S
4
N
4
P
4
C
4
Q
4
S
4
351
N
4
G
4
E
4
C
4
V
4
E
4
L
4
S
4
S
4
E
4
361
K
4
Q
4
Y
4
G
4
R
4
I
4
T
4
G
4
L
4
P
4
371
S
4
S
4
F
4
S
4
Y
4
H
4
E
4
A
4
S
4
G
4
381
Y
4
V
4
C
4
I
4
C
4
Q
4
P
4
G
4
F
4
T
4
391
G
4
I
4
H
4
C
4
E
4
E
4
D
4
V
4
N
4
E
4
401
C
4
S
4
S
4
N
4
P
4
C
4
Q
4
N
4
G
4
G
4
411
T
4
C
4
E
4
N
4
L
4
P
4
G
4
N
4
Y
4
T
4
421
C
4
H
4
C
4
P
4
F
4
D
4
N
4
L
4
S
4
R
4
431
T
4
F
4
Y
4
G
4
G
4
R
4
D
4
C
4
S
4
D
4
441
I
4
L
4
L
4
G
4
C
4
T
4
H
4
Q
4
Q
4
C
4
451
L
4
N
4
N
4
G
4
T
4
C
4
I
4
P
4
H
4
F
4
461
Q
4
D
4
G
4
Q
4
H
4
G
4
F
4
S
4
C
4
L
4
471
C
4
P
4
S
4
G
4
Y
4
T
4
G
4
S
4
L
4
C
1
481
E
1
I
1
A
1
T
1
T
1
L
1
S
1
F
1
E
1
G
1
491
D
1
G
1
F
1
L
1
W
1
V
1
K
1
S
1
G
1
S
1
501
V
1
T
1
T
1
K
1
G
1
S
1
V
1
C
1
N
1
I
1
511
A
1
L
1
R
1
F
1
Q
1
T
1
V
1
Q
1
P
1
M
1
521
A
1
L
1
L
1
L
1
F
1
R
1
S
1
N
1
R
1
D
1
531
V
1
F
1
V
1
K
1
L
1
E
1
L
1
L
1
S
1
G
1
541
Y
1
I
1
H
1
L
1
S
1
I
1
Q
1
V
1
N
1
N
1
551
Q
1
S
1
K
1
V
1
L
1
L
1
F
1
I
1
S
1
H
1
561
N
1
T
1
S
1
D
1
G
1
E
1
W
1
H
1
F
1
V
1
571
E
1
V
1
I
1
F
1
A
1
E
1
A
1
V
1
T
1
L
1
581
T
1
L
1
I
1
D
1
D
1
S
1
C
1
K
1
E
1
K
1
591
C
1
I
1
A
1
K
1
A
1
P
1
T
1
P
1
L
1
E
1
601
S
1
D
1
Q
1
S
1
I
1
C
1
A
1
F
1
Q
1
N
1
611
S
1
F
1
L
1
G
1
G
1
L
1
P
1
V
1
G
1
M
1
621
T
1
S
1
N
1
G
1
V
1
A
1
L
1
L
1
N
1
F
1
631
Y
1
N
1
M
1
P
1
S
1
T
1
P
1
S
1
F
1
V
1
641
G
1
C
1
L
1
Q
1
D
1
I
1
K
1
I
1
D
1
W
1
651
N
1
H
1
I
1
T
1
L
1
E
1
N
1
I
1
S
1
S
1
661
G
1
S
1
S
1
L
1
N
1
V
1
K
1
A
1
G
1
C
1
671
V
1
R
1
K
1
D
1
W
1
C
1
E
1
S
1
Q
1
P
1
681
C
1
Q
1
S
1
R
1
G
1
R
1
C
1
I
1
N
1
L
1
691
W
1
L
1
S
1
Y
1
Q
1
C
1
D
1
C
1
H
1
R
1
701
P
1
Y
1
E
1
G
1
P
1
N
1
C
1
L
1
R
1
E
1
711
Y
1
V
1
A
1
G
1
R
1
F
1
G
1
Q
1
D
1
D
1
721
S
1
T
1
G
1
Y
1
V
1
I
1
F
1
T
1
L
1
D
1
731
E
1
S
1
Y
1
G
1
D
1
T
1
I
1
S
1
L
1
S
1
741
M
1
F
1
V
1
R
1
T
1
L
1
Q
1
P
1
S
1
G
1
751
L
1
L
1
L
1
A
1
L
1
E
1
N
1
S
1
T
1
Y
1
761
Q
1
Y
1
I
1
R
1
V
1
W
1
L
1
E
1
R
1
G
1
771
R
1
L
1
A
1
M
1
L
1
T
1
P
1
N
1
S
1
P
1
781
K
1
L
1
V
1
V
1
K
1
F
1
V
1
L
1
N
1
D
1
791
G
1
N
1
V
1
H
1
L
1
I
1
S
1
L
1
K
1
I
1
801
K
1
P
1
Y
1
K
1
I
1
E
1
L
1
Y
1
Q
1
S
1
811
S
1
Q
1
N
1
L
1
G
1
F
1
I
1
S
1
A
1
S
1
821
T
1
W
1
K
1
I
1
E
1
K
1
G
1
D
1
V
1
I
1
831
Y
1
I
1
G
1
G
1
L
1
P
1
D
1
K
1
Q
1
E
1
841
T
1
E
1
L
1
N
1
G
1
G
1
F
1
F
1
K
1
G
1
851
C
1
I
1
Q
1
D
1
V
1
R
1
L
1
N
1
N
1
Q
1
861
N
1
L
1
E
1
F
1
F
1
P
1
N
1
P
1
T
1
N
1
871
N
1
A
1
S
1
L
1
N
1
P
1
V
1
L
1
V
1
N
1
881
V
1
T
1
Q
1
G
1
C
1
A
1
G
1
D
1
N
1
S
1
891
C
1
K
1
S
1
N
1
P
1
C
1
H
1
N
1
G
1
G
1
901
V
1
C
1
H
1
S
1
R
1
W
1
D
1
D
1
F
1
S
1
911
C
1
S
1
C
1
P
1
A
1
L
1
T
1
S
1
G
1
K
1
921
A
1
C
1
E
1
E
1
V
1
Q
1
W
1
C
1
G
1
F
1
931
S
1
P
1
C
1
P
1
H
1
G
1
A
1
Q
1
C
1
Q
1
941
P
1
V
1
L
1
Q
1
G
1
F
1
E
1
C
1
I
1
A
1
951
N
1
A
1
V
1
F
1
N
1
G
1
Q
1
S
1
G
1
Q
1
961
I
1
L
1
F
1
R
1
S
1
N
1
G
1
N
1
I
1
T
1
971
R
1
E
1
L
1
T
1
N
1
I
1
T
1
F
1
G
1
F
1
981
R
1
T
1
R
1
D
1
A
1
N
1
V
1
I
1
I
1
L
1
991
H
1
A
1
E
1
K
1
E
1
P
1
E
1
F
1
L
1
N
1
1001
I
1
S
1
I
1
Q
1
D
1
S
1
R
1
L
1
F
1
F
1
1011
Q
1
L
1
Q
1
S
1
G
1
N
1
S
1
F
1
Y
1
M
1
1021
L
1
S
1
L
1
T
1
S
1
L
1
Q
1
S
1
V
1
N
1
1031
D
1
G
1
T
1
W
1
H
1
E
1
V
1
T
1
L
1
S
1
1041
M
1
T
1
D
1
P
1
L
1
S
1
Q
1
T
1
S
1
R
1
1051
W
1
Q
1
M
1
E
1
V
1
D
1
N
1
E
1
T
1
P
1
1061
F
1
V
1
T
1
S
1
T
1
I
1
A
1
T
1
G
1
S
1
1071
L
1
N
1
F
1
L
1
K
1
D
1
N
1
T
1
D
1
I
1
1081
Y
1
V
1
G
1
D
1
R
1
A
1
I
1
D
1
N
1
I
1
1091
K
1
G
1
L
1
Q
1
G
1
C
1
L
1
S
1
T
1
I
1
1101
E
1
I
1
G
1
G
1
I
1
Y
1
L
1
S
1
Y
1
F
1
1111
E
1
N
1
V
1
H
1
G
1
F
1
I
1
N
1
K
1
P
1
1121
Q
1
E
1
E
1
Q
1
F
1
L
1
K
1
I
1
S
1
T
1
1131
N
1
S
1
V
1
V
1
T
1
G
1
C
1
L
1
Q
1
L
1
1141
N
1
V
1
C
1
N
1
S
1
N
1
P
1
C
1
L
1
H
1
1151
G
1
G
1
N
1
C
1
E
1
D
1
I
1
Y
1
S
1
S
1
1161
Y
1
H
1
C
1
S
1
C
1
P
1
L
1
G
1
W
1
S
1
1171
G
1
K
1
H
1
C
1
E
1
L
1
N
1
I
1
D
1
E
1
1181
C
1
F
1
S
1
N
1
P
1
C
1
I
1
H
5
G
5
N
5
1191
C
5
S
5
D
5
R
5
V
5
A
5
A
5
Y
5
H
5
C
5
1201
T
5
C
5
E
5
P
5
G
5
Y
5
T
5
G
5
V
5
N
5
1211
C
5
E
5
V
5
D
5
I
5
D
5
N
5
C
5
Q
5
S
5
1221
H
5
Q
5
C
5
A
5
N
5
G
5
A
5
T
5
C
5
I
5
1231
S
5
H
5
T
5
N
5
G
5
Y
5
S
5
C
5
L
5
C
5
1241
F
5
G
5
N
5
F
5
T
5
G
5
K
5
F
5
C
5
R
5
1251
Q
5
S
5
R
5
L
5
P
5
S
5
T
5
V
5
C
5
G
5
1261
N
5
E
5
K
5
T
5
N
5
L
5
T
5
C
5
Y
5
N
5
1271
G
5
G
5
N
5
C
5
T
5
E
5
F
5
Q
5
T
5
E
5
1281
L
5
K
5
C
5
M
5
C
5
R
5
P
5
G
5
F
5
T
5
1291
G
5
E
5
W
5
C
5
E
5
K
5
D
5
I
5
D
5
E
5
1301
C
5
A
5
S
5
D
5
P
5
C
5
V
5
N
5
G
5
G
5
1311
L
5
C
5
Q
5
D
5
L
5
L
5
N
5
K
5
F
5
Q
5
1321
C
5
L
5
C
5
D
5
V
5
A
5
F
5
A
5
G
5
E
5
1331
R
5
C
5
E
5
V
5
D
5
L
5
A
5
D
5
D
5
L
5
1341
I
5
S
5
D
5
I
5
F
5
T
6
T
6
I
6
G
6
S
6
1351
V
6
T
6
V
6
A
6
L
6
L
6
L
6
I
6
L
6
L
6
1361
L
6
A
6
I
6
V
6
A
6
S
6
V
6
V
6
T
6
S
6
1371
N
6
K
6
R
6
A
6
T
6
Q
6
G
6
T
6
Y
6
S
6
1381
P
6
S
6
R
6
Q
6
E
6
K
6
E
6
G
6
S
6
R
6
1391
V
6
E
6
M
6
W
6
N
6
L
6
M
6
P
6
P
6
P
6
1401
A
6
M
6
E
6
R
6
L
6
I
6

 

Section II. Summary Prediction Results

Summary (help)
Download
detailed prediction results.
To open .zip files, you may use 7-zip for Windows or unzip for Linux/Unix/MacOS.
Status
Current status:
Complete
Submitted on:
2017-11-27 04:13
Scheduled on:
2017-11-27 06:23
Finished on:
2017-11-27 08:41

Section III. Detailed Prediction Results (you can see each result entry by clicking on it)

[+] Click to view the predicted results in the CAMEO format
[+] Click to view 3D model and binding site residues for domain 1 [480, 1187] P-value:4.21e-19